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10.1016/j.cmet.2018.03.001 9 DruckerD

Key Takeaways Vitamin B12 injections are essential for treating deficiencies

Trauma or injury may be a risk factor

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Remarkably, significant conformational changes of ECL1 upon receptor activation were observed relative to their inactive conformations: (i) in the inactive GCGR, ECL1 forms a -hairpin conformation and further compacts -sheet with the stalk region